Dados do Trabalho

Título

Impact of anesthetic technique on serum troponin levels in pediatric patients undergoing surgical correction of congenital heart defects: a randomized clinical trial

Objetivo

The primary objective of this study is to assess the impact of different anesthetic techniques, specifically sevoflurane inhalational anesthesia versus total intravenous anesthesia (TIVA), on serum troponin I levels within the first 48 hours postoperatively in pediatric patients undergoing congenital heart defect surgery. Secondary objectives include evaluating other cardiac biomarkers (CKMB, CPK, BNP), renal function parameters (serum creatinine, urea levels, urine output), and clinical outcomes such as duration of mechanical ventilation, ICU/hospital stay, and incidence of postoperative complications.

Métodos

The study was a randomized clinical trial with 66 pediatric patients divided into two groups: one receiving sevoflurane anesthesia and the other total intravenous anesthesia (TIVA). Patients were monitored for troponin I levels, cardiac biomarkers, and renal function within the first 48 hours post-surgery.

Resultados

The use of sevoflurane did not result in a statistically significant reduction in serum troponin I levels compared to TIVA. However, the sevoflurane group showed higher urine output and lower serum urea levels on the second postoperative day.

Conclusão

While sevoflurane did not significantly impact myocardial injury markers, it may offer benefits for renal function in this patient population. Further research is necessary to confirm these findings across different pediatric age groups and surgical contexts.